関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Uracil | HCID 1174 | — |
| 反応物 | p-Fluoronitrobenzene | HCID 9590 | — |
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1-(4-Nitrophenyl)pyrimidine-2,4-dione | HCID 11276338 | — |
反応手順
A mixture of 3.5 g 1H-Pyrimidine-2,4-dione and 3 g 1-Fluoro-4-nitro-benzene and 13.8 g Cs2CO3 in 60 mL DMF was heated to 80° C. for 12 h. This solution was poured on to 200 mL of water and the resulting precipitate was collected by filtration to yield a bright yellow crystalline product, which was dried under reduced pressure. Yield: 2.6 g.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07741341B2 |
|---|
| 出典データセット | uspto-grants-2010_06 |
|---|
| ORD ID | ord-d6ab52a054f44054930b84bdf35417b4 |
|---|
| 出典メモ | uspto-grants-2010_06 |
|---|
