Hydrochloric Acid → HCID 178462368、化合物

HRID 1853479ノート

反応式

HRID 1853479 の反応式
[OH:1][C@H:2]([CH3:22])[C:3]([NH:5][C@H:6]1[CH2:11][CH2:10][C@H:9]([C@H:12]([NH:14]C(=O)OC(C)(C)C)[CH3:13])[CH2:8][CH2:7]1)=[O:4].Cl.O1CCOCC1>ClCCl>[NH2:14][C@@H:12]([C@H:9]1[CH2:8][CH2:7][C@H:6]([NH:5][C:3](=[O:4])[C@H:2]([OH:1])[CH3:22])[CH2:11][CH2:10]1)[CH3:13]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 178462369HCID 178462369、化合物

生成物 1

HCID 178462368HCID 178462368、化合物収率 100%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Trans-tert-butyl(R)-1-(4-((R)-2-hydroxypropanamido)cyclohexyl)ethylcarbamate (66 mg, 0.21 mmol) was dissolved in dichloromethane (10 mL). A solution of HCl in dioxane (209.9 μL of 4 M, 0.84 mmol) was added. The reaction mixture was stirred at ambient temperature for 18 hours. The crude mixture was concentrated in vacuo and coevaporated three times with diethylether. The residue was dissolved in methanol (10 mL), passed through a sodium bicarbonate cartridge and concentrated in vacuo to give the desired compound as a white solid (45 mg, quantitative yield).

後処理

  1. concentrationThe crude mixture was concentrated in vacuo
  2. dissolutionThe residue was dissolved in methanol (10 mL)
  3. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-ca3d3467848e4ac19696b9f280953c39
出典データセット
uspto-grants-2015_02
特許番号
US08962642B2

反応ノート

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