Divinyl sulfone → [4-(1,1-Dioxo-1lambda6-thiomorpholin-4-yl)-phenyl]-carbamic acid tert-butyl ester

HRID 18537

反応式

HRID 18537 の反応式
[C:1]([O:5][C:6](=[O:15])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][CH:9]=1)([CH3:4])([CH3:3])[CH3:2].[CH:16]([S:18]([CH:21]=[CH2:22])(=[O:20])=[O:19])=[CH2:17]>CCO>[C:1]([O:5][C:6](=[O:15])[NH:7][C:8]1[CH:9]=[CH:10][C:11]([N:14]2[CH2:22][CH2:21][S:18](=[O:20])(=[O:19])[CH2:16][CH2:17]2)=[CH:12][CH:13]=1)([CH3:4])([CH3:2])[CH3:3]

参加物

4

反応物 2

HCID 6496Divinyl sulfoneHCID 688611tert-Butyl (4-aminophenyl)carbamate

生成物 1

HCID 68616091[4-(1,1-Dioxo-1lambda6-thiomorpholin-4-yl)-phenyl]-carbamic acid tert-butyl ester

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 408 mg (4-Amino-phenyl)-carbamic acid tert-butyl ester and 254 mg Ethenesulfonyl-ethene in 4 mL EtOH were heated for 30 min at 140° C. under microwave irradiation (100 W, CEM Discover™ apparatus). Then, after cooling to RT the solvents were removed under reduced pressure and the residue was dried in vacuo. The crude product was subjected to the next reaction step.

後処理

  1. customwere removed under reduced pressure
  2. customthe residue was dried in vacuo
  3. customThe crude product was subjected to the next reaction step

出典と根拠

ORDレコード
ord-770f859b938246188dc93593dd1d1dc5
出典データセット
uspto-grants-2010_06
特許番号
US07741341B2

関連ノート

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