Water → HCID 23086769、化合物

HRID 18538ノート

反応式

HRID 18538 の反応式
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[O-:7].[Na+].F[C:10]1[CH:15]=[CH:14][C:13]([N+:16]([O-:18])=[O:17])=[CH:12][CH:11]=1.C([O-])([O-])=O.[Cs+].[Cs+].O>CN(C=O)C>[N+:16]([C:13]1[CH:14]=[CH:15][C:10]([N:1]2[CH:6]=[CH:5][N:4]=[CH:3][C:2]2=[O:7])=[CH:11][CH:12]=1)([O-:18])=[O:17]

参加物

6

反応物 4

HCID 962WaterHCID 9590p-FluoronitrobenzeneHCID 10796Cesium carbonateHCID 236689732(1H)-Pyrazinone, sodium salt (1:1)

生成物 1

HCID 23086769HCID 23086769、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
35 °C

実験手順

A mixture of 632 mg Sodium pyrazin-2-olate and 720 mg 1-Fluoro-4-nitro-benzene and 3.3 g Cs2CO3 in 13 mL DMF was heated to 35° C. for 6 h. This solution was poured on to 300 mL of water and the resulting precipitate was collected by filtration to yield a bright yellow crystalline product, which was dried under reduced pressure. Yield: 545 mg.

後処理

  1. filtrationthe resulting precipitate was collected by filtration
  2. customto yield a bright yellow crystalline product, which
  3. customwas dried under reduced pressure

出典と根拠

ORDレコード
ord-dd3cb375507c46c8b46d939f3caf9af4
出典データセット
uspto-grants-2010_06
特許番号
US07741341B2

反応ノート

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