HCID 23086769、化合物 → 1-(4-Aminophenyl)pyrazin-2(1H)-one
反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH:15]=[CH:14][N:13]=[CH:12][C:11]2=[O:16])=[CH:6][CH:5]=1)([O-])=O>C(OCC)(=O)C.C(O)C>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([N:10]2[CH:15]=[CH:14][N:13]=[CH:12][C:11]2=[O:16])=[CH:8][CH:9]=1参加物
4
実験手順
To a solution of 520 mg 1-(4-Nitro-phenyl)-1H-pyrazin-2-one in 26 mL ethyl acetate and 1.3 mL ethanol, 2.7 g SnCl2 dihydrate were added and the reaction mixture was heated to reflux for 6 h. Then, after cooling to RT the mixture was stirred for 16 h. The precipitated product was collected by filtration and was pure enough for the next reaction step. Yield: 450 mg.
後処理
- temperaturethe reaction mixture was heated
- temperatureto reflux for 6 h
- filtrationThe precipitated product was collected by filtration
- customwas pure enough for the next reaction step
出典と根拠
- ORDレコード
- ord-6aa73413b96e48a6a0c5bd166d0a548c
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07741341B2
反応ノート
読み込み中…