Borane;tetrahydrofuran → 1-[1-(4-Bromophenyl)cyclopropyl]methanamine
反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:11]#[N:12])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.B.C1COCC1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([CH2:11][NH2:12])[CH2:9][CH2:10]2)=[CH:6][CH:7]=1参加物
3
実験手順
Following the procedure outlined for Example 666, 1-(4-bromophenyl)cyclopropane carbonitrile (2.0 g, 9.0 mmol) was reacted with BH3.THF (1.0 M in THF, 50 mL, 50 mmol) to afford the desired product (1.9 g, 94%) as a yellow oil: ESI MS m/z 226 [C10H12BrN+H]+.
出典と根拠
- ORDレコード
- ord-dd0fd6b6bd85428abd2f8032c04c1d81
- 出典データセット
- uspto-grants-2015_02
- 特許番号
- US08962648B2
反応ノート
読み込み中…