Ethylamine → N-Ethyl-4-bromobenzylamine

反応式

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8]Br)=[CH:4][CH:3]=1.[CH2:10]([NH2:12])[CH3:11]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH:12][CH2:10][CH3:11])=[CH:4][CH:3]=1

参加物

反応物 2

HCID 6341Ethylamine

HCID 685274-Bromobenzyl bromide

生成物 1

HCID 4716477N-Ethyl-4-bromobenzylamine収率 75.9%

実験手順

Following the procedure outlined for Example 488, 1-bromo-4-(bromomethyl)benzene (2.0 g, 8.0 mmol) was reacted with ethanamine (720 mg, 16 mmol) to afford the desired product (1.3 g, 75%) as a brown solid: ESI MS m/z 215 [C9H12BrN+H]+.

出典と根拠

ORDレコード: ord-1a26f87c973348ab9dc589b9c4020042
出典データセット: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08962648B2

反応ノート

読み込み中…