Ammonia → 1-(4-Aminophenyl)piperazin-2-one

HRID 18540ノート

反応式

HRID 18540 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH:15]=[CH:14][N:13]=[CH:12][C:11]2=[O:16])=[CH:6][CH:5]=1)([O-])=O.N.[H][H]>CO.[Ni]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][C:11]2=[O:16])=[CH:8][CH:9]=1

参加物

6

反応物 3

HCID 222AmmoniaHCID 23086769HCID 23086769、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 534061751-(4-Aminophenyl)piperazin-2-one

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒2 回

実験手順

To a solution of 670 mg 1-(4-Nitro-phenyl)-1H-pyrazin-2-one in 100 mL MeOH, 8 g Raney Nickel (washed three times with MeOH) were introduced under a nitrogen atmosphere. Then 10 mL of a 7 M solution of NH3 in MeOH were added. The nitrogen atmosphere was replaced by a hydrogen atmosphere and the mixture was hydrogenated under normal pressure at RT. After 2 h the reaction mixture was filtered through a pad of celite. The solvents were removed under reduced pressure and the residue was subjected to the next reaction step without further purification.

後処理

  1. customwas hydrogenated under normal pressure at RT
  2. filtrationAfter 2 h the reaction mixture was filtered through a pad of celite
  3. customThe solvents were removed under reduced pressure
  4. customthe residue was subjected to the next reaction step without further purification

出典と根拠

ORDレコード
ord-c83c3cd7ec4f44a284775955b7ce9cbc
出典データセット
uspto-grants-2010_06
特許番号
US07741341B2

反応ノート

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