化工社化工社 化学情報印刷レポート · 研究参考用
Water → 2-(2-Methoxyethoxy)-6-nitroaniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Bromoethyl methyl ether | HCID 80972 | — |
| 反応物 | 2-Amino-3-Nitrophenol | HCID 4115495 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-(2-Methoxyethoxy)-6-nitroaniline | HCID 59349604 | — |
反応手順
A solution of 5 g 2-Amino-3-nitro-phenol, 4.5 g 1-Bromo-2-methoxy-ethane, 4.4 g K2CO3 in 50 mL DMF were heated to 60° C. for 16 h. Then 50 mL of water were added and the mixture was extracted with ethyl acetate (3×100 ml). The combined organic layers were dried over MgSO4, and the solvents were removed under reduced pressure. The remaining product was pure enough for the next reaction step. Yield: 5.8 g.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07741341B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-e4212dad419940b0b09a993a75280f66 |
| 出典メモ | uspto-grants-2010_06 |