Water → 2-(2-Methoxyethoxy)-6-nitroaniline

HRID 18541

反応式

HRID 18541 の反応式
[NH2:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][C:3]=1[OH:11].Br[CH2:13][CH2:14][O:15][CH3:16].C([O-])([O-])=O.[K+].[K+].O>CN(C=O)C>[CH3:16][O:15][CH2:14][CH2:13][O:11][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]([N+:8]([O-:10])=[O:9])[C:2]=1[NH2:1]

参加物

6

反応物 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 809722-Bromoethyl methyl etherHCID 41154952-Amino-3-Nitrophenol

生成物 1

HCID 593496042-(2-Methoxyethoxy)-6-nitroaniline

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A solution of 5 g 2-Amino-3-nitro-phenol, 4.5 g 1-Bromo-2-methoxy-ethane, 4.4 g K2CO3 in 50 mL DMF were heated to 60° C. for 16 h. Then 50 mL of water were added and the mixture was extracted with ethyl acetate (3×100 ml). The combined organic layers were dried over MgSO4, and the solvents were removed under reduced pressure. The remaining product was pure enough for the next reaction step. Yield: 5.8 g.

後処理

  1. extractionthe mixture was extracted with ethyl acetate (3×100 ml)
  2. dry with materialThe combined organic layers were dried over MgSO4
  3. customthe solvents were removed under reduced pressure
  4. customThe remaining product was pure enough for the next reaction step

出典と根拠

ORDレコード
ord-e4212dad419940b0b09a993a75280f66
出典データセット
uspto-grants-2010_06
特許番号
US07741341B2

関連ノート

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