HCID 68551182、化合物 → HCID 68554115、化合物

HRID 1854685ノート

反応式

HRID 1854685 の反応式
C(OC([NH:8][CH2:9][C:10]([NH:12][C:13]1[CH:18]=[CH:17][C:16](/[CH:19]=[CH:20]/[C:21](=[O:34])[CH2:22][C:23](=[O:33])/[CH:24]=[CH:25]/[C:26]2[CH:31]=[CH:30][C:29]([OH:32])=[CH:28][CH:27]=2)=[CH:15][CH:14]=1)=[O:11])=O)(C)(C)C.C(OC(NC1C=CC(/C=C/C(=O)CC(=O)/C=C/C2C=CC(O)=CC=2)=CC=1)=O)(C)(C)C>C(Cl)(Cl)Cl.CO>[NH2:8][CH2:9][C:10]([NH:12][C:13]1[CH:14]=[CH:15][C:16](/[CH:19]=[CH:20]/[C:21](=[O:34])[CH2:22][C:23](=[O:33])/[CH:24]=[CH:25]/[C:26]2[CH:31]=[CH:30][C:29]([OH:32])=[CH:28][CH:27]=2)=[CH:17][CH:18]=1)=[O:11]

参加物

4

反応物 2

HCID 68551182HCID 68551182、化合物HCID 68551771HCID 68551771、化合物

生成物 1

HCID 68554115HCID 68554115、化合物

試薬・触媒・溶媒 1

HCID 21584188Chloroform methanol溶媒

実験手順

The title compound was synthesized using the same procedure employed for Example 281, but with (1E,6E)-1-{4-[2-(tert-butoxycarbonylamino)acetylamino]phenyl}-7-(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione (18 mg, 39 μmol, synthesized in Example 268) as the starting material instead of (1E,6E)-1-[4-(tert-butoxycarbonylamino)phenyl]-7-(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione, and was purified by silica gel chromatography (chloroform/methanol=95/5 to 80/20). The product was obtained as a solid (1.5 mg, 11%) having the following characteristic.

出典と根拠

ORDレコード
ord-a476c9f7b5334091a3f5e06d92fe56fa
出典データセット
uspto-grants-2015_02
特許番号
US08962674B2

反応ノート

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