2-chloro-4-methyl-6-(N-methyl-2-hydroxyethylamino)pyrimidine → 2-({2-[3-Methoxy-4-(4-methyl-imidazol-1-yl)-phenylamino]-6-methyl-pyrimidin-4-yl}-methyl-amino)-ethanol

HRID 1855455

反応式

HRID 1855455 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH2:15])[CH:6]=[CH:7][C:8]=1[N:9]1[CH:13]=[C:12]([CH3:14])[N:11]=[CH:10]1.Cl[C:17]1[N:22]=[C:21]([N:23]([CH3:27])[CH2:24][CH2:25][OH:26])[CH:20]=[C:19]([CH3:28])[N:18]=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:15][C:17]2[N:22]=[C:21]([N:23]([CH3:27])[CH2:24][CH2:25][OH:26])[CH:20]=[C:19]([CH3:28])[N:18]=2)[CH:6]=[CH:7][C:8]=1[N:9]1[CH:13]=[C:12]([CH3:14])[N:11]=[CH:10]1

参加物

3

反応物 2

HCID 183238282-chloro-4-methyl-6-(N-methyl-2-hydroxyethylamino)pyrimidineHCID 454801813-methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline

生成物 1

HCID 441932802-({2-[3-Methoxy-4-(4-methyl-imidazol-1-yl)-phenylamino]-6-methyl-pyrimidin-4-yl}-methyl-amino)-ethanol収率 57%

実験手順

Prepared in analogy to example 81b) from 3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamine and 2-[(2-chloro-6-methyl-pyrimidin-4-yl)-methyl-amino]ethanol. The title compound was isolated as a colorless solid in a yield of 57%. MS ISP (m/e): 369.2 (100) [(M+H)+]. 1H NMR (CDCl3, 300 MHz): δ (ppm)=7.70 (d, 1H), 7.60 (s, 1H), 7.11 (d, 1H), 7.05-6.90 (m, 2H), 6.85 (s, 1H), 5.92 (s, 1H), 3.95-3.80 (m, 2H), 3.84 (s, 3H), 3.80-3.70 (m, 2H), 3.12 (s, 3H), 2.31 (s, 3H), 2.29 (s, 3H).

出典と根拠

ORDレコード
ord-e4a91c00ee7c415ab49b058a3e7bea80
出典データセット
uspto-grants-2015_02
特許番号
US08962834B2

関連ノート

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