Methyl chloroacetate → 2-Chloro-N-(2,3-dihydroxypropyl)acetamide

HRID 1855745ノート

反応式

HRID 1855745 の反応式
[NH2:1][CH2:2][CH:3]([OH:6])[CH2:4][OH:5].[Cl:7][CH2:8][C:9](OC)=[O:10]>CO>[OH:6][CH:3]([CH2:4][OH:5])[CH2:2][NH:1][C:9](=[O:10])[CH2:8][Cl:7]

参加物

4

反応物 2

HCID 7295Methyl chloroacetateHCID 735613-Amino-1,2-propanediol

生成物 1

HCID 132331202-Chloro-N-(2,3-dihydroxypropyl)acetamide収率 95%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

A solution of 25 grams (g) (0.27 mole) of 3-amino-1,2-propanediol in 50 milliliter (ml) methyl alcohol is added slowly to a solution of methyl chloroacetate, 33.0 g (0.30 mole) in 50 ml methyl alcohol at 5°-10° C. The solution is stirred for five hours at 5°-10° C. and is then allowed to stand in the cold for four days. The solution is then evaporated in vacuum to leave 43 g of the desired product, a viscous oil, nD30 1.5148. (95% yield).

後処理

  1. customcold for four days
  2. customThe solution is then evaporated in vacuum

出典と根拠

ORDレコード
ord-1f665d27a2c4407eb0df2c437dd7952b
出典データセット
uspto-grants-1980_08
特許番号
US04216222

反応ノート

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