1-[2-(3-Bromophenyl)propyl]-2-(cyclohexylmethyl)piperidine → 2,6-Dichlorobenzaldehyde
反応式
C1(CC2CCCCN2CC(C2C=CC=C([CH:23]([OH:32])[C:24]3[C:29]([Cl:30])=[CH:28][CH:27]=[CH:26][C:25]=3[Cl:31])C=2)C)CCCCC1.C1(CC2CCCCN2CC(C2C=CC=C(Br)C=2)C)CCCCC1.C([Li])CCC>C(OCC)C>[Cl:30][C:29]1[CH:28]=[CH:27][CH:26]=[C:25]([Cl:31])[C:24]=1[CH:23]=[O:32]参加物
5
実験手順
2-Cyclohexylmethyl-1-{2-[3-(α-hydroxy-2,6-dichlorobenzyl)phenyl]propyl}piperidine (yellow oil) prepared by reaction of 18.9 g. (0.05 mole) of 2-cyclohexylmethyl-1-[2-(3-bromophenyl)propyl]piperidine with 0.1 mole of butyl lithium in diethyl ether followed by 19.2 g. (0.11 mole) of 2,6-dichlorobenzaldehyde to give 19.3 g. of product.
出典と根拠
- ORDレコード
- ord-439e779db6f34f9b9384415e653ce4d7
- 出典データセット
- uspto-grants-1980_08
- 特許番号
- US04216326
反応ノート
読み込み中…