Hydrochloric Acid → 2-(2-Indenyl)-3-methylbutanoic acid

HRID 1855950ノート

反応式

HRID 1855950 の反応式
[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[CH:10]([CH:28]([CH3:30])[CH3:29])[C:11]([O:13]CC1C=CC=C(OC2C=CC=CC=2)C=1)=[O:12].[OH-].[K+].C(O)C.Cl>O>[CH2:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH:1]=[C:2]1[CH:10]([CH:28]([CH3:30])[CH3:29])[C:11]([OH:13])=[O:12]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14797Potassium HydroxideHCID 13146349m-Phenoxylbenzyl 2-(2-indenyl)-3-methylbutanoate

生成物 1

HCID 233470912-(2-Indenyl)-3-methylbutanoic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of m-phenoxybenzyl 2-(2-indenyl)-3-methylbutanoate (8 mmol), potassium hydroxide (24 mmol), ethanol (25 ml) and water (4 ml) is heated to reflux for about 3 hours. After cooling, the reaction is acidified with dilute hydrochloric acid. The mixture is extracted with ether, and the ether phase is washed to neutrality with saturated NaCl solution. Removal of solvent by evaporation yields 2-(2-indenyl)-3-methylbutanoic acid.

後処理

  1. temperatureis heated
  2. temperatureto reflux for about 3 hours
  3. temperatureAfter cooling
  4. extractionThe mixture is extracted with ether
  5. washthe ether phase is washed to neutrality with saturated NaCl solution
  6. customRemoval of solvent
  7. customby evaporation

出典と根拠

ORDレコード
ord-609db78ab8d241ce8b49aba049ae0309
出典データセット
uspto-grants-1980_08
特許番号
US04217302

反応ノート

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