Potassium Cyanide → 2-(1-Bromonaphthalen-2-yl)acetonitrile
反応式
[Br:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[CH2:12]Br.[C-:14]#[N:15].[K+]>[Cl-].C([N+](CC)(CC)CC)C1C=CC=CC=1.C(Cl)Cl.O>[Br:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[CH2:12][C:14]#[N:15]参加物
6
実験手順
A mixture of 99 parts of 1-bromo-2-(bromomethyl)naphthalene, 103 parts of potassium cyanide and 1 part of benzyl triethylammonium chloride in 150 parts by volume of methylene chloride and 30 parts by volume of water is stirred at room temperature for about 72 hours. The mixture is then diluted with additional quantities of methylene chloride and water, the organic layer separated, dried over calcium sulfate, and concentrated to give α-(1-bromo-2-naphthyl)acetonitrile, as a solid.
後処理
- customthe organic layer separated
- dry with materialdried over calcium sulfate
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-3bf92dfc906f4dae8a086f25c09d43de
- 出典データセット
- uspto-grants-1980_08
- 特許番号
- US04217306
反応ノート
読み込み中…