1-(1H-Imidazol-1-yl)ethanone → HCID 23347409、化合物

HRID 1856008ノート

反応式

HRID 1856008 の反応式
[N:1]1([CH2:6][C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[NH:9][CH:8]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.[C:16](N1C=CN=C1)(=[O:18])[CH3:17]>>[C:16]([N:9]1[C:10]2[C:15](=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:7]([CH2:6][N:1]2[CH:5]=[CH:4][N:3]=[CH:2]2)=[CH:8]1)(=[O:18])[CH3:17]

参加物

3

反応物 2

HCID 171741-(1H-Imidazol-1-yl)ethanoneHCID 7924863-(imidazol-1-ylmethyl)-1H-indole

生成物 1

HCID 23347409HCID 23347409、化合物収率 42.5%

実験手順

A mixture consisting of 3-(imidazol-1-ylmethyl)indole (0.97 g) and 1-acetylimidazole (1.10 g) was heated on a steam bath for a period of 3.5 hours to give an orange oil, which soon solidied on cooling. The resulting solid product was then chromatographed on silica gel. Elution with chloroform first gave some minor impurity, followed by the pure product. The product-containing fractions were then combined and subsequently evaporated to dryness while under reduced pressure to afford a solid residue, which was thereafter crystallized from ethyl acetate to yield pure 1-acetyl-3-(imidazol-1-ylmethyl)indole (yield, 0.50 g.), m.p. 122° C.

後処理

  1. temperaturewas heated on a steam bath for a period of 3.5 hours
  2. customto give an orange oil, which
  3. temperatureon cooling
  4. customThe resulting solid product was then chromatographed on silica gel
  5. washElution with chloroform
  6. customfirst gave some minor impurity
  7. customsubsequently evaporated to dryness while under reduced pressure
  8. customto afford a solid residue, which
  9. customwas thereafter crystallized from ethyl acetate

出典と根拠

ORDレコード
ord-8854147abbd941e4953808eb4891f5bc
出典データセット
uspto-grants-1980_08
特許番号
US04217357

反応ノート

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