化工社化工社 化学情報印刷レポート · 研究参考用
Acetic Acid → (1,1'-Biphenyl)-4-butanoic acid, gamma-hydroxy-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Fenbufen | HCID 3335 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | (1,1'-Biphenyl)-4-butanoic acid, gamma-hydroxy- | HCID 16072199 | — |
反応手順
A 25.4 g. portion of 3-(4-biphenylylcarbonyl)propionic acid is dissolved in 2 liters of water made alkaline with sodium hydroxide. A 37.8 g. portion of sodium borohydride is added and the mixture is stirred for 2 hours. The suspension is then slowly poured into 100 ml. of glacial acetic acid. The mixture is cooled and the resulting solid is filtered, washed with water and dried giving the desired product, m.p. 139°-140° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04219668 |
| 出典データセット | uspto-grants-1980_08 |
| ORD ID | ord-683b6ab37ab6474ab8171af01f918ae9 |
| 出典メモ | uspto-grants-1980_08 |