Sodium Bicarbonate → HCID 54532474、化合物

HRID 1856584ノート

反応式

HRID 1856584 の反応式
C(=O)(O)[O-].[Na+].[CH3:6][C:7]1([CH3:17])[C@@H:9]([CH2:10][C:11](=O)[CH3:12])[C@H:8]1[C:14]([OH:16])=[O:15].Cl.[CH:19]([O:22][NH2:23])([CH3:21])[CH3:20]>O>[CH3:6][C:7]1([CH3:17])[C@@H:9]([CH2:10][C:11](=[N:23][O:22][CH:19]([CH3:21])[CH3:20])[CH3:12])[C@H:8]1[C:14]([OH:16])=[O:15]

参加物

5

反応物 3

HCID 516892Sodium BicarbonateHCID 10899111(1R,3S)-2,2-Dimethyl-3-(2-oxopropyl)cyclopropanecarboxylic acidHCID 12696235O-(propan-2-yl)hydroxylamine hydrochloride

生成物 1

HCID 54532474HCID 54532474、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a solution of 1.85 g of sodium bicarbonate in 50 ml of water, were added 1.70 g of (1R,cis)-2,2-dimethyl-3-(2-oxopropyl)cyclopropanecarboxylic acid and 1.15 g of isopropoxyamine hydrochloride at room temperature. The reaction mixture was stirred at room temperature for 4.5 hours and filtered through celite. The filtrate was acidified with concentrated hydrochloric acid to a pH of 2, and extracted with methylene chloride. The organic extract was washed with a sodium chloride solution, dried over magnesium sulfate, stripped and concentrated under high vacuum to give the desired product as a slightly amber oil.

後処理

  1. filtrationfiltered through celite
  2. extractionextracted with methylene chloride
  3. extractionThe organic extract
  4. washwas washed with a sodium chloride solution
  5. dry with materialdried over magnesium sulfate
  6. concentrationconcentrated under high vacuum

出典と根拠

ORDレコード
ord-1aca39c92e3d4a5890524e63f503cdbc
出典データセット
uspto-grants-1980_08
特許番号
US04219563

反応ノート

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