1-Amino-2-propanol → 6-[3-(2-Hydroxypropyl)aminopropoxy]carbostyril
反応式
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[NH:12][C:11](=[O:16])[CH:10]=[CH:9]2.[NH2:17][CH2:18][CH:19]([OH:21])[CH3:20]>CC(O)C>[OH:21][CH:19]([CH3:20])[CH2:18][NH:17][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[NH:12][C:11](=[O:16])[CH:10]=[CH:9]2参加物
4
実験手順
6-(3-Chloropropoxy)carbostyril (5 g) and 1-amino-2-propanol (24 ml) are dissolved in 2-propanol (100 ml), and the mixture is refluxed for 4 hours. After the reaction mixture is allowed to cool, the precipitated crystals are collected by filtration, washed with ethanol, and dried to give 6-[3-(2-hydroxypropyl)aminopropoxy]carbostyril (3.1 g) as a white powder.
後処理
- temperaturethe mixture is refluxed for 4 hours
- temperatureto cool
- filtrationthe precipitated crystals are collected by filtration
- washwashed with ethanol
- customdried
出典と根拠
- ORDレコード
- ord-a66b798be5f1449780fce0489f7550c2
- 出典データセット
- uspto-grants-2000_11
- 特許番号
- US06143763
反応ノート
読み込み中…