N-tert-butoxy-1-[4-(4-chlorobenzoyl)piperidine-1-sulfonyl]piperidine-2-(R)-carboxamide → N-hydroxy-1-[4-(4-chlorobenzoyl)-piperidine-1-sulfonyl]piperidine-2-(R)-carboxamide

HRID 1856869

反応式

HRID 1856869 の反応式
C([O:5][NH:6][C:7]([C@H:9]1[CH2:14][CH2:13][CH2:12][CH2:11][N:10]1[S:15]([N:18]1[CH2:23][CH2:22][CH:21]([C:24](=[O:32])[C:25]2[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=2)[CH2:20][CH2:19]1)(=[O:17])=[O:16])=[O:8])(C)(C)C>ClCCCl>[OH:5][NH:6][C:7]([C@H:9]1[CH2:14][CH2:13][CH2:12][CH2:11][N:10]1[S:15]([N:18]1[CH2:19][CH2:20][CH:21]([C:24](=[O:32])[C:25]2[CH:26]=[CH:27][C:28]([Cl:31])=[CH:29][CH:30]=2)[CH2:22][CH2:23]1)(=[O:17])=[O:16])=[O:8]

参加物

3

反応物 1

HCID 18727273N-tert-butoxy-1-[4-(4-chlorobenzoyl)piperidine-1-sulfonyl]piperidine-2-(R)-carboxamide

生成物 1

HCID 15434917N-hydroxy-1-[4-(4-chlorobenzoyl)-piperidine-1-sulfonyl]piperidine-2-(R)-carboxamide収率 51%

試薬・触媒・溶媒 1

HCID 111,2-Dichloroethane溶媒

実験手順

A solution of N-tert-butoxy-1-[4-(4-chlorobenzoyl)piperidine-1-sulfonyl]piperidine-2-(R)-carboxamide (100 mg, 0.22 mmol), [prepared as described in Step 1 above], in 1,2-dichloroethane (10 ml) was cooled to -30° C. and HCl gas was bubbled through it for 10 min. The reaction vessel was then sealed and stirred at RT. After 2 days, the reaction mixture was vented with nitrogen and then concentrated in vacuo. The residue was chromatographed (PTLC, SiO2, 10% methanol/methylene chloride) to give N-hydroxy-1-[4-(4-chlorobenzoyl)piperidine-1-sulfonyl]piperidine-2-(R)-carboxamide as a white solid (51%), mp 84.4-86.4° C.

後処理

  1. customHCl gas was bubbled through it for 10 min
  2. customThe reaction vessel was then sealed
  3. concentrationconcentrated in vacuo
  4. customThe residue was chromatographed (PTLC, SiO2, 10% methanol/methylene chloride)

出典と根拠

ORDレコード
ord-e7a6b8ef7f8e476ab77def49b91ceac6
出典データセット
uspto-grants-2000_11
特許番号
US06143744

関連ノート

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