Hydrochloric Acid → HCID 54470793、化合物

HRID 1856908ノート

反応式

HRID 1856908 の反応式
[OH:1][C:2]1[CH:11]=[CH:10][C:5]2[C:6](=[O:9])[CH2:7][O:8][C:4]=2[CH:3]=1.[Cl:12][C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][C:20]=1[NH2:21])[CH:16]=O.Cl>CO>[Cl:12][C:13]1[CH:14]=[C:15]([CH:16]=[C:7]2[C:6](=[O:9])[C:5]3[CH:10]=[CH:11][C:2]([OH:1])=[CH:3][C:4]=3[O:8]2)[CH:18]=[CH:19][C:20]=1[NH2:21]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 2357176-Hydroxy-3-coumaranoneHCID 132977934-Amino-3-chlorobenzaldehyde

生成物 1

HCID 54470793HCID 54470793、化合物収率 91.3%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

After 6-hydroxy-2H-benzofuran-3-one 1 g and 3-chloro-4-aminobenzaldehyde 1.24 g were dissolved in methanol 75 ml, concentrated hydrochloric acid 50 ml was added, and the mixture was refluxed for 1.5 hours. The solution was cooled to room temperature, and precipitated crystals were filtered and dried over phosphorous pentoxide at a temperature of 60° C. for five hours under reduced pressure to obtain the desired compound 1.75 g.

後処理

  1. temperaturethe mixture was refluxed for 1.5 hours
  2. customprecipitated crystals
  3. filtrationwere filtered
  4. dry with materialdried over phosphorous pentoxide at a temperature of 60° C. for five hours under reduced pressure

出典と根拠

ORDレコード
ord-fe3ce813370f4afaa58b335c7cf54d54
出典データセット
uspto-grants-2000_11
特許番号
US06143779

反応ノート

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