Butyl isocyanate → HCID 22667145、化合物

HRID 1857224ノート

反応式

HRID 1857224 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][N:7]=[C:6]2[O:15][C:16]1[CH:21]=[CH:20][C:19]([NH2:22])=[CH:18][CH:17]=1.[CH2:23]([N:27]=[C:28]=[O:29])[CH2:24][CH2:25][CH3:26]>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][N:7]=[C:6]2[O:15][C:16]1[CH:21]=[CH:20][C:19]([NH:22][C:28]([NH:27][CH2:23][CH2:24][CH2:25][CH3:26])=[O:29])=[CH:18][CH:17]=1

参加物

4

反応物 2

HCID 8110Butyl isocyanateHCID 116163634-(6,7-Dimethoxyquinazolin-4-yloxy)aniline

生成物 1

HCID 22667145HCID 22667145、化合物収率 56%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

6,7-Dimethoxy-4-(4-aminophenoxy)quinazoline (100 mg) was dissolved in toluene (10 ml) with heat, n-butyl isocyanate (0.29 ml) was added, and the admixture was refluxed with heat for 40 minutes. After removing the solvent by distillation, the resulting residue was purified by column chromatography on silica gel eluting with chloroform/acetone (5/1) to obtain 75 mg of the title compound (yield: 56%).

後処理

  1. temperaturewith heat
  2. temperaturethe admixture was refluxed
  3. temperaturewith heat for 40 minutes
  4. customAfter removing the solvent
  5. distillationby distillation
  6. customthe resulting residue was purified by column chromatography on silica gel eluting with chloroform/acetone (5/1)

出典と根拠

ORDレコード
ord-1fe79b7dff5246f9839e32ba7e24cc06
出典データセット
uspto-grants-2000_11
特許番号
US06143764

反応ノート

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