2-Chloro-4-nitrophenyl isocyanate → N-(2-Chloro-4-nitrophenyl)-N'-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}urea

HRID 1857239ノート

反応式

HRID 1857239 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][CH:7]=[C:6]2[O:15][C:16]1[CH:21]=[CH:20][C:19]([NH2:22])=[CH:18][CH:17]=1.[Cl:23][C:24]1[CH:29]=[C:28]([N+:30]([O-:32])=[O:31])[CH:27]=[CH:26][C:25]=1[N:33]=[C:34]=[O:35]>C1(C)C=CC=CC=1>[Cl:23][C:24]1[CH:29]=[C:28]([N+:30]([O-:32])=[O:31])[CH:27]=[CH:26][C:25]=1[NH:33][C:34]([NH:22][C:19]1[CH:18]=[CH:17][C:16]([O:15][C:6]2[C:5]3[C:10](=[CH:11][C:12]([O:13][CH3:14])=[C:3]([O:2][CH3:1])[CH:4]=3)[N:9]=[CH:8][CH:7]=2)=[CH:21][CH:20]=1)=[O:35]

参加物

4

反応物 2

HCID 46142212-Chloro-4-nitrophenyl isocyanateHCID 115945434-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline

生成物 1

HCID 22132755N-(2-Chloro-4-nitrophenyl)-N'-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}urea収率 100%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

6,7-Dimethoxy-4-(4-aminophenoxy)quinoline (104 mg) was dissolved in toluene (10 ml) with heat, 2-chloro-4-nitrophenyl isocyanate (150 mg) was added, and the admixture was refluxed with heat for 10 minutes. The separated crystals were filtered and then washed with toluene to obtain 172 mg of the title compound (yield: 100%).

後処理

  1. temperaturewith heat
  2. temperaturethe admixture was refluxed
  3. temperaturewith heat for 10 minutes
  4. filtrationThe separated crystals were filtered
  5. washwashed with toluene

出典と根拠

ORDレコード
ord-5a3db80752e64930aa9e3bf0a86418ad
出典データセット
uspto-grants-2000_11
特許番号
US06143764

反応ノート

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