Methanesulfonic Acid → 3-Ethylaniline mesylate

HRID 1857353ノート

反応式

HRID 1857353 の反応式
[CH2:1]([C:3]1[CH:4]=[C:5]([CH:7]=[CH:8][CH:9]=1)[NH2:6])[CH3:2].[CH3:10][S:11]([OH:14])(=[O:13])=[O:12]>CO>[S:11]([OH:14])(=[O:13])(=[O:12])[CH3:10].[CH2:1]([C:3]1[CH:4]=[C:5]([CH:7]=[CH:8][CH:9]=1)[NH2:6])[CH3:2]

参加物

4

反応物 2

HCID 6395Methanesulfonic AcidHCID 114753-Ethylaniline

生成物 1

HCID 867560113-Ethylaniline mesylate収率 91%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
25 °C

実験手順

To a solution of 3-ethylaniline (Aldrich, 4.84 g, 40 mmol) in methanol (10 mL) was added methanesulfonic acid (4.4 g, 45 mmol) at 4° C., then the reaction mixture was stirred at 25° C. for 30 minutes to yield a solution with white precipitates. The precipitates were collected by filtration, washed with ether, and dried under vacuum to afford 7.7 g of 3-ethylaniline mesylate (7.7 g, 91% yield).

後処理

  1. customto yield a solution with white precipitates
  2. filtrationThe precipitates were collected by filtration
  3. washwashed with ether
  4. customdried under vacuum

出典と根拠

ORDレコード
ord-ccd1dad765f44c448a901bc2538729c2
出典データセット
uspto-grants-2000_11
特許番号
US06147063

反応ノート

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