(3-Bromophenyl)acetyl chloride → 2-[2-(3-Bromophenyl)-acetylamino]-4-chloro-5-nitrobenzoic acid methyl ester

HRID 1857613ノート

反応式

HRID 1857613 の反応式
[CH3:1][O:2][C:3](=[O:15])[C:4]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[C:7]([Cl:13])=[CH:6][C:5]=1[NH2:14].[Br:16][C:17]1[CH:18]=[C:19]([CH2:23][C:24](Cl)=[O:25])[CH:20]=[CH:21][CH:22]=1>ClC(Cl)C>[CH3:1][O:2][C:3](=[O:15])[C:4]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[C:7]([Cl:13])=[CH:6][C:5]=1[NH:14][C:24](=[O:25])[CH2:23][C:19]1[CH:20]=[CH:21][CH:22]=[C:17]([Br:16])[CH:18]=1

参加物

4

反応物 2

HCID 13486899(3-Bromophenyl)acetyl chlorideHCID 15895692Methyl 2-amino-4-chloro-5-nitrobenzoate

生成物 1

HCID 537529782-[2-(3-Bromophenyl)-acetylamino]-4-chloro-5-nitrobenzoic acid methyl ester

試薬・触媒・溶媒 1

HCID 63651,1-Dichloroethane溶媒

実験手順

To a suspension of 2-amino-4-chloro-5-nitrobenzoic acid methyl ester (Example 9, 780 mg in 10 mL dichloroethane) was added a solution of (3-bromophenyl)acetyl chloride (prepared essentially as described in Example 9, 866 mg in 5 mL dichloroethane) and the mixture heated to reflux on an oil bath. After 18 hours, the reaction mixture was concentrated in vacuo and the title compound obtained by crystallization from methanol (1.18 g).

後処理

  1. customprepared essentially
  2. temperatureheated
  3. temperatureto reflux on an oil bath
  4. concentrationthe reaction mixture was concentrated in vacuo

出典と根拠

ORDレコード
ord-e0de2d9d4b1944f3bfe09d5798f4fb36
出典データセット
uspto-grants-2000_11
特許番号
US06147088

反応ノート

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