Methyl 4-chloroanthranilate → 4-Chloro-2-[2-(3,5-dimethylphenyl)-acetylamino]-benzoic acid methyl ester

HRID 1857626ノート

反応式

HRID 1857626 の反応式
[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][C:5]=1[NH2:11].[CH3:13][C:14]1[CH:15]=[C:16]([CH2:21][C:22](Cl)=[O:23])[CH:17]=[C:18]([CH3:20])[CH:19]=1>>[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][C:5]=1[NH:11][C:22](=[O:23])[CH2:21][C:16]1[CH:15]=[C:14]([CH3:13])[CH:19]=[C:18]([CH3:20])[CH:17]=1

参加物

3

反応物 2

HCID 80001Methyl 4-chloroanthranilateHCID 15895699(3,5-Dimethylphenyl)acetyl chloride

生成物 1

HCID 544849894-Chloro-2-[2-(3,5-dimethylphenyl)-acetylamino]-benzoic acid methyl ester収率 90.6%

実験手順

To a solution of (3,5-dimethylphenyl)acetyl chloride (2.58 g in 20 mL dry dichloroethane) was added 2.5 g 2-amino-4-chlorobenzoic acid methyl ester and the mixture heated to reflux on an oil bath. After 2 hours, the pot was cooled to room temperature and the solvent removed in vacuo. Recrystallization of the crude product from methanol gave the title compound (4.05 g).

後処理

  1. temperaturethe mixture heated
  2. temperatureto reflux on an oil bath
  3. customthe solvent removed in vacuo
  4. customRecrystallization of the crude product from methanol

出典と根拠

ORDレコード
ord-73d697ff42214d9db0de91482510aafd
出典データセット
uspto-grants-2000_11
特許番号
US06147088

反応ノート

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