Methyl 2-amino-4-chloro-5-iodobenzoate → 4-Chloro-2-[2-(3,5-dimethylphenyl)-acetylamino]-5-iodo-benzoic acid methyl ester

HRID 1857630

反応式

HRID 1857630 の反応式
[CH3:1][O:2][C:3](=[O:13])[C:4]1[CH:9]=[C:8]([I:10])[C:7]([Cl:11])=[CH:6][C:5]=1[NH2:12].[CH3:14][C:15]1[CH:16]=[C:17]([CH2:22][C:23](Cl)=[O:24])[CH:18]=[C:19]([CH3:21])[CH:20]=1>>[CH3:1][O:2][C:3](=[O:13])[C:4]1[CH:9]=[C:8]([I:10])[C:7]([Cl:11])=[CH:6][C:5]=1[NH:12][C:23](=[O:24])[CH2:22][C:17]1[CH:16]=[C:15]([CH3:14])[CH:20]=[C:19]([CH3:21])[CH:18]=1

参加物

3

反応物 2

HCID 10852539Methyl 2-amino-4-chloro-5-iodobenzoateHCID 15895699(3,5-Dimethylphenyl)acetyl chloride

生成物 1

HCID 540909164-Chloro-2-[2-(3,5-dimethylphenyl)-acetylamino]-5-iodo-benzoic acid methyl ester

反応条件

温度
75 °C

実験手順

To a solution of 2-amino-4-chloro-5-iodo-benzoic acid methyl ester (2.26 g in 25 mL dichloroethane) was added (3,5-dimethylphenyl) acetyl chloride (1.2 g in 15 mL dichloroethane) and the mixture heated to 75° C. on an oil bath. After 3 hours, the reaction was cooled and the solvent removed in vacuo. The title compound was isolated by crystallization from methanol (2.7 g).

後処理

  1. temperaturethe reaction was cooled
  2. customthe solvent removed in vacuo

出典と根拠

ORDレコード
ord-135bf16af6e24199a6363aebf26854a5
出典データセット
uspto-grants-2000_11
特許番号
US06147088

関連ノート

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