Hydrochloric Acid → HCID 22130877、化合物
反応式
C([O:8][CH2:9][C:10]1[N:11]([CH3:27])[C:12]([CH2:18][C:19]2[CH:24]=[C:23]([Cl:25])[CH:22]=[C:21]([Cl:26])[CH:20]=2)=[C:13]([CH:15]([CH3:17])[CH3:16])[N:14]=1)C1C=CC=CC=1.Cl>C(O)C>[Cl:26][C:21]1[CH:20]=[C:19]([CH:24]=[C:23]([Cl:25])[CH:22]=1)[CH2:18][C:12]1[N:11]([CH3:27])[C:10]([CH2:9][OH:8])=[N:14][C:13]=1[CH:15]([CH3:16])[CH3:17]参加物
4
反応条件
- 温度
- 110 °C
実験手順
In 3 ml of ethanol was dissolved 470 mg (1.17 mmol) of 2-benzyloxymethyl-5-(3,5-dichlorobenzyl)-4-isopropyl-1-methyl-1H-imidazole (58), followed by addition of 10 ml of concentrated hydrochloric acid (36% aqueous solution), and the mixture was refluxed under heating at 110° C. After 3 hours, the reaction mixture was concentrated under reduced pressure, neutralized with aqueous sodium hydroxide, and extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated. To the crude crystals, 5 ml of diethyl ether was added, and filtered to give 350 mg of [5-(3,5-dichlorobenzyl)-4-isopropyl-1-methyl-1H-imidazol-2-yl]methanol (59a) (yield 95.9%).