Potassium Hydroxide → 6-(1,4-Dioxa-8-azaspiro[4,5]dec-8-yl)-1,3,5-triazine-2,4-diamine

HRID 1857942ノート

反応式

HRID 1857942 の反応式
[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[N:5]=[C:4](Cl)[N:3]=1.[O:10]1[C:14]2([CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)[O:13][CH2:12][CH2:11]1.[OH-].[K+]>O1CCOCC1.C(O)C.O>[O:10]1[C:14]2([CH2:19][CH2:18][N:17]([C:4]3[N:3]=[C:2]([NH2:1])[N:7]=[C:6]([NH2:8])[N:5]=3)[CH2:16][CH2:15]2)[O:13][CH2:12][CH2:11]1

参加物

7

反応物 3

HCID 14797Potassium HydroxideHCID 188311,3,5-Triazine-2,4-diamine, 6-chloro-HCID 674351,4-Dioxa-8-azaspiro(4.5)decane

生成物 1

HCID 98164366-(1,4-Dioxa-8-azaspiro[4,5]dec-8-yl)-1,3,5-triazine-2,4-diamine

試薬・触媒・溶媒 3

HCID 702Ethanol溶媒HCID 962Water溶媒HCID 312751,4-Dioxane溶媒

実験手順

A mixture of 2,4-diamino-6-chloro-1,3,5-triazine (2 g, 14 mmol), 1,4-dioxa-8-azaspiro[4.5]decane (3 g, 21 mmol), and KOH (100 mg, 1.8 mmol) in dioxane (10 mL) and ethanol (40 mL) was heated at reflux overnight, diluted with water, and filtered. The precipitate was rinsed with water and dried under vacuum to provide the title compound.

後処理

  1. temperaturewas heated
  2. temperatureat reflux overnight
  3. filtrationfiltered
  4. washThe precipitate was rinsed with water
  5. customdried under vacuum

出典と根拠

ORDレコード
ord-698fd8cabfbe49b284e7f0777a4faaf4
出典データセット
uspto-grants-2000_11
特許番号
US06150362

反応ノート

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