Acetyl chloride → 1-(4-Chloro-2-fluoro-5-methylphenyl)ethanone

HRID 1857968ノート

反応式

HRID 1857968 の反応式
[C:1](Cl)(=[O:3])[CH3:2].[Cl:5][C:6]1[CH:11]=[C:10]([F:12])[CH:9]=[CH:8][C:7]=1[CH3:13].[Cl-].[Al+3].[Cl-].[Cl-]>Cl>[CH3:13][C:7]1[CH:8]=[C:9]([C:1]([CH3:2])=[O:3])[C:10]([F:12])=[CH:11][C:6]=1[Cl:5]

参加物

5

反応物 3

HCID 6367Acetyl chlorideHCID 967472-Chloro-4-fluorotolueneHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 27365641-(4-Chloro-2-fluoro-5-methylphenyl)ethanone

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

反応条件

温度
120 °C

実験手順

At 60° C., 157 g of acetyl chloride were added dropwise to a mixture of 250 g of 2-chloro-4-fluorotoluene and 267 g of aluminum chloride. The reaction mixture was stirred at 120° C. for 2 hours and then, while still at 100° C., poured onto 2 l of an ice/water mixture. 180 ml of concentrated hydrochloric acid were subsequently stirred into the resulting mixture. The product was then extracted using three times 200 ml of dichloromethane. The organic phase was then washed with 200 ml of water, dried over sodium sulfate and finally concentrated. Yield: 290 g; oil.

後処理

  1. extractionThe product was then extracted
  2. washThe organic phase was then washed with 200 ml of water
  3. dry with materialdried over sodium sulfate
  4. concentrationfinally concentrated

出典と根拠

ORDレコード
ord-56e843515cb84acab58e1c2333dc5328
出典データセット
uspto-grants-2000_11
特許番号
US06150303

反応ノート

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