16698-08-1 → 5,7-Dimethyl-hexahydro-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-1H-1,4-diazepine hydrochloride

反応式

[CH3:1][CH:2]1[CH2:8][CH:7]([CH3:9])[NH:6][CH2:5][CH2:4][NH:3]1.[Cl:10][S:11]([C:14]1[CH:23]=[CH:22][CH:21]=[C:20]2[C:15]=1[C:16]([CH3:24])=[CH:17][N:18]=[CH:19]2)(=[O:13])=[O:12]>>[ClH:10].[CH3:1][CH:2]1[CH2:8][CH:7]([CH3:9])[N:6]([S:11]([C:14]2[CH:23]=[CH:22][CH:21]=[C:20]3[C:15]=2[C:16]([CH3:24])=[CH:17][N:18]=[CH:19]3)(=[O:12])=[O:13])[CH2:5][CH2:4][NH:3]1

参加物

反応物 2

HCID 639609416698-08-1

HCID 154871104-Methylisoquinoline-5-sulfonyl chloride

生成物 1

HCID 221219495,7-Dimethyl-hexahydro-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-1H-1,4-diazepine hydrochloride収率 68.1%

実験手順

Using 0.77 g of 5,7-dimethyl-hexahydro-1H-1,4-diazepine and 0.48 g of 5-chlorosulfonyl-4-methylisoquinoline, the procedure of Example 1 was otherwise repeated to provide 0.50 g of the objective compound (white crystals).

出典と根拠

ORDレコード: ord-d44a91c506c74c64a85e60ac8d869e28
出典データセット: uspto-grants-2000_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06153608

反応ノート

読み込み中…