Cyanogen Bromide → 2-Chloro-5-ethylphenylcyanamide

HRID 1858986ノート

反応式

HRID 1858986 の反応式
[Cl:1][C:2]1[CH:8]=[CH:7][C:6]([CH2:9][CH3:10])=[CH:5][C:3]=1[NH2:4].Br[C:12]#[N:13]>O>[Cl:1][C:2]1[CH:8]=[CH:7][C:6]([CH2:9][CH3:10])=[CH:5][C:3]=1[NH:4][C:12]#[N:13]

参加物

4

反応物 2

HCID 10476Cyanogen BromideHCID 124650462-Chloro-5-ethylaniline

生成物 1

HCID 105593012-Chloro-5-ethylphenylcyanamide収率 100.3%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a heterogeneous slurry of 2-chloro-5-ethylaniline (1.6 g, 10 mmol) in 60 mL of water at 4° C. was added solid BrCN (0.848 g, 8 mmol) slowly. After 5 minutes the cooling bath was removed and the heterogeneous reaction mixture was stirred at room temperature for 24 hours to yield the product in water suspension. The precipitates were collected by filtration, washed with water (100 mL), and dried under vacuum to yield the pure title compound (1.45 g, 80% yield).

後処理

  1. customAfter 5 minutes the cooling bath was removed
  2. customto yield the product in water suspension
  3. filtrationThe precipitates were collected by filtration
  4. washwashed with water (100 mL)
  5. customdried under vacuum

出典と根拠

ORDレコード
ord-63774565f3e0431f925976ea2cb9b52a
出典データセット
uspto-grants-2000_11
特許番号
US06153604

反応ノート

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