Benzaldehyde → 2-Benzylidene-1,3-indandione

HRID 1859077

反応式

HRID 1859077 の反応式
[C:1]1(=[O:11])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3](=[O:10])[CH2:2]1.[CH:12](=O)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C1C=CC=CC=1.N1CCCCC1>[CH:12](=[C:2]1[C:1](=[O:11])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:10])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

参加物

5

反応物 2

HCID 240BenzaldehydeHCID 118151,3-Indandione

生成物 1

HCID 2378222-Benzylidene-1,3-indandione収率 72.1%

試薬・触媒・溶媒 2

HCID 8082Piperidine触媒HCID 241Benzene溶媒

実験手順

To a solution of 1,3-indandione (43.8 g) and piperidine (44 mg) in dry benzene (500 ml) was added benzaldhyde (31.8 g). The mixture was heated to reflux and the water generated was removed by Dean-Stark trap. After 24 hours, the mixture was evaporated to dryness. The residue was recrystallized from ethanol (200 ml) to give 2-benzylidene-1,3-indandione as a yellow solid (50.6 g).

後処理

  1. temperatureThe mixture was heated
  2. temperatureto reflux
  3. customthe water generated was removed by Dean-Stark trap
  4. customthe mixture was evaporated to dryness
  5. customThe residue was recrystallized from ethanol (200 ml)

出典と根拠

ORDレコード
ord-4cdc2d56b9d643e9bb22b4106b8ec394
出典データセット
uspto-grants-2000_11
特許番号
US06153645

関連ノート

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