Water → 2,2'-(2,5-Dioxopiperazine-1,4-diyl)diacetic acid

HRID 1859259ノート

反応式

HRID 1859259 の反応式
[C:1]([N:4]([CH2:9][C:10]([OH:12])=O)[CH2:5][C:6]([OH:8])=[O:7])(=[O:3])[CH3:2].[OH2:13]>C(O)(=O)C>[C:6]([CH2:5][N:4]1[CH2:2][C:1](=[O:3])[N:4]([CH2:5][C:6]([OH:8])=[O:7])[CH2:9][C:10]1=[O:12])([OH:7])=[O:13]

参加物

4

反応物 2

HCID 962WaterHCID 10130190N-acetyliminodiacetic acid

生成物 1

HCID 235108522,2'-(2,5-Dioxopiperazine-1,4-diyl)diacetic acid

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
195 °C

実験手順

N-acetyliminodiacetic acid (XVI) monohydrate (45 g) and varying amounts of water and acetic acid were heated at 175° C. or 195° C. for various periods of time. After cooling to room temperature, the mixture was filtered. The solid was washed with water (10 mL) and dried to give 1,4-di(carboxymethyl)-2,5-diketopiperazine. The table below shows the yields of solid under various conditions.

後処理

  1. temperatureAfter cooling to room temperature
  2. filtrationthe mixture was filtered
  3. washThe solid was washed with water (10 mL)
  4. customdried

出典と根拠

ORDレコード
ord-17dfbc30ca9d4fd8b1bb1863a4fe8c94
出典データセット
uspto-grants-2000_11
特許番号
US06153753

反応ノート

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