Water → 2-(4-Methoxyphenyl)prop-2-enoic acid
反応式
O[C:2]([C:7]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[CH:9][CH:8]=1)([CH3:6])[C:3]([OH:5])=[O:4].S(=O)(=O)(O)O.O>O1CCOCC1>[CH3:14][O:13][C:10]1[CH:9]=[CH:8][C:7]([C:2](=[CH2:6])[C:3]([OH:5])=[O:4])=[CH:12][CH:11]=1参加物
5
実験手順
2-Hydroxy-2-(4-methoxyphenyl)propionic acid (35 g, 178 mmol) was dissolved in dioxane (700 ml) and concentrated sulfuric acid (60 ml) was added thereto. The reaction mixture was refluxed for 2 hours under heating. The reaction solution was cooled and, after adding water, extracted with ethyl acetate. The organic layer was washed with saturated sodium thiosulfate solution and water, dried over anhydrous magnesium sulfate and then concentrated under reduced pressure to obtain 24.8 g (yield: 72%) of the title compound as a brown solid.
後処理
- temperatureThe reaction mixture was refluxed for 2 hours
- temperatureunder heating
- temperatureThe reaction solution was cooled
- extractionextracted with ethyl acetate
- washThe organic layer was washed with saturated sodium thiosulfate solution and water
- dry with materialdried over anhydrous magnesium sulfate
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-682fd67c9479434aa8ebc41887bd4154
- 出典データセット
- uspto-grants-2000_11
- 特許番号
- US06153768
反応ノート
読み込み中…