Ethanol → 1-(4,4,5,5,5-Pentafluoropentyl)piperazine

HRID 1859347ノート

反応式

HRID 1859347 の反応式
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.C(O)C.[F:10][C:11]([F:31])([C:27]([F:30])([F:29])[F:28])[CH2:12][CH2:13][CH2:14]OC1C=CC=C(C)C=1S([O-])(=O)=O>O>[F:10][C:11]([F:31])([C:27]([F:30])([F:29])[F:28])[CH2:12][CH2:13][CH2:14][N:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1

参加物

5

反応物 3

HCID 702EthanolHCID 4837PiperazineHCID 867560744,4,5,5,5-Pentafluoropentyloxytoluenesulfonate

生成物 1

HCID 221236141-(4,4,5,5,5-Pentafluoropentyl)piperazine収率 100%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Piperazine (777 mg, 9.0 mmol) was added to ethanol solution (10 ml) of 4,4,5,5,5-pentafluoropentyloxytoluenesulfonate (600 mg, 1.81 mmol) and then heated under refluxing for 40 hours. After adding water, the reaction solution was extracted with ethyl acetate. The solvent was distilled off under reduced pressure from the extract to obtain 315 mg (yield: 100%) of the title compound.

後処理

  1. temperatureheated
  2. temperatureunder refluxing for 40 hours
  3. extractionthe reaction solution was extracted with ethyl acetate
  4. distillationThe solvent was distilled off under reduced pressure from the
  5. extractionextract

出典と根拠

ORDレコード
ord-f963d98051544e3db366144d0bfe444d
出典データセット
uspto-grants-2000_11
特許番号
US06153768

反応ノート

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