(r)-5,11-Dihydro-5-[1-(4-methoxyphenethyl)piperidine-2-ylmethyl] dibenzo[b,e][1,4]oxazepine → (r)-5,11-Dihydro-5-[1-(4-methoxyphenethyl)piperidine-2-ylmethyl] dibenzo[b,e][1,4] oxazepine hydrochloride

HRID 1859427ノート

反応式

HRID 1859427 の反応式
[ClH:1].C(OCC)(=O)C.[CH3:8][O:9][C:10]1[CH:39]=[CH:38][C:13]([CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][CH2:19][CH2:18][C@@H:17]2[CH2:22][N:23]2[C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=3[CH2:27][O:26][C:25]3[CH:34]=[CH:35][CH:36]=[CH:37][C:24]2=3)=[CH:12][CH:11]=1>ClCCl>[ClH:1].[CH3:8][O:9][C:10]1[CH:11]=[CH:12][C:13]([CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][CH2:19][CH2:18][C@@H:17]2[CH2:22][N:23]2[C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=3[CH2:27][O:26][C:25]3[CH:34]=[CH:35][CH:36]=[CH:37][C:24]2=3)=[CH:38][CH:39]=1

参加物

4

反応物 2

HCID 15520941(r)-5,11-Dihydro-5-[1-(4-methoxyphenethyl)piperidine-2-ylmethyl] dibenzo[b,e][1,4]oxazepineHCID 21866389Hydrogen chloride-ethyl acetate

生成物 1

HCID 22975054(r)-5,11-Dihydro-5-[1-(4-methoxyphenethyl)piperidine-2-ylmethyl] dibenzo[b,e][1,4] oxazepine hydrochloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

0.5 ml of 4 M hydrochloric acid/ethyl acetate was added to a solution of (R)-5,11-dihydro-5-[1-(4-methoxyphenethyl)piperidine-2-ylmethyl]dibenzo[b,e][1,4]oxazepine (78 mg) in dichloromethane (5 ml), and they were stirred for 2 hours. The solvent was evaporated under reduced pressure. The title compound was obtained in the form of a light yellow solid (75 mg, 90%).

後処理

  1. customThe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-6d4dbc418a764d44a55aade617e88c8e
出典データセット
uspto-grants-2003_03
特許番号
US06528504B2

反応ノート

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