化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Iodide → 4-Methyl-1-thiophen-3-yl-pentan-3-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Iodide | HCID 5238 | — |
| 反応物 | Triphenylphosphine | HCID 11776 | — |
| 反応物 | 3-Bromothiophene | HCID 13383 | — |
| 反応物 | 4-Methyl-1-penten-3-ol | HCID 20929 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 触媒 | palladium(II) acetate | HCID 167845 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-Methyl-1-thiophen-3-yl-pentan-3-one | HCID 12477279 | — |
反応手順
The title compound was prepared according to General Method 4b using 3-bromothiophene (20 mmol), 4-methyl-1-penten-3-ol (30 mmol), sodium iodide (0.7 mmol), sodium bicarbonate (24 mmol), triphenylphosphine (0.6 mmol), DMF (15 mL), and palladium acetate (0.2 mmol). The title compound was flash chromatographed using EtOAc:hexane (5:95 to 10:90).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06528510B1 |
| 出典データセット | uspto-grants-2003_03 |
| ORD ID | ord-344f539b93384784a326a21ef037d6ff |
| 出典メモ | uspto-grants-2003_03 |