Potassium Carbonate → 5-Isopropyl-2-nitroaniline

HRID 1859555ノート

反応式

HRID 1859555 の反応式
FC(F)(F)C([NH:5][C:6]1[CH:11]=[C:10]([CH:12]([CH3:14])[CH3:13])[CH:9]=[CH:8][C:7]=1[N+:15]([O-:17])=[O:16])=O.C(=O)([O-])[O-].[K+].[K+]>CO.O>[CH:12]([C:10]1[CH:9]=[CH:8][C:7]([N+:15]([O-:17])=[O:16])=[C:6]([NH2:5])[CH:11]=1)([CH3:14])[CH3:13]

参加物

5

反応物 2

HCID 11430Potassium CarbonateHCID 225730622,2,2-Trifluoro-N-(5-isopropyl-2-nitro-phenyl)-acetamide

生成物 1

HCID 225728525-Isopropyl-2-nitroaniline

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

2,2,2-Trifluoro-N-(5-isopropyl-2-nitro-phenyl)-acetamide (prepared in Example OO-1; 9.4 g, 34 mmol) was dissolved in MeOH (30 mL) and treated with 7% aqueous potassium carbonate solution. The reaction mixture was stirred overnight at room temperature. The reaction was diluted with water (30 mL) and extracted with EtOAc (3×50 mL). The organic layer was washed with saturated NaHCO3 solution and brine, dried (MgSO4), and concentrated. The crude product was used further without any purification. MS(APCI): 181 (M+H).

後処理

  1. extractionextracted with EtOAc (3×50 mL)
  2. washThe organic layer was washed with saturated NaHCO3 solution and brine
  3. dry with materialdried (MgSO4)
  4. concentrationconcentrated
  5. customThe crude product was used further without any purification

出典と根拠

ORDレコード
ord-c5e5da97a19e44b8b2db18b23ded8d49
出典データセット
uspto-grants-2003_03
特許番号
US06528510B1

反応ノート

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