Methyl 2,2,2-trichloroacetimidate → 4-(2-Methoxy-ethoxy)-2-trichloromethyl-1H-benzoimidazole

関与物質

反応手順

1.33 g (7.30 mmol) 3-(2-Methoxy-ethoxy)-benzene-1,2-diamine were dissolved in 35 mL acetic acid. 1.25 mL (10.22 mmol) 2,2,2-trichloro-acetimidic acid methyl ester were added and the resulting mixture was stirred for 2 h at room temperature. The mixture was concentrated under reduced pressure and the residue was co-distilled twice with 20 mL toluene to give crude 4-(2-Methoxy-ethoxy)-2-trichloromethyl-1H-benzoimidazole as a brown solid.

情報源と証拠