Potassium Cyanide → 3-(3-Methoxy-4-methylphenyl)propyl cyanide

HRID 1859809ノート

反応式

HRID 1859809 の反応式
Br[CH2:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][C:8]([CH3:11])=[C:7]([O:12][CH3:13])[CH:6]=1.[C-:14]#[N:15].[K+]>CC(C)=O.CCO.O>[CH3:13][O:12][C:7]1[CH:6]=[C:5]([CH2:4][CH2:3][CH2:2][C:14]#[N:15])[CH:10]=[CH:9][C:8]=1[CH3:11]

参加物

6

反応物 2

HCID 9032Potassium CyanideHCID 186265044-(3-Bromopropyl)-2-methoxy-1-methylbenzene

生成物 1

HCID 186265273-(3-Methoxy-4-methylphenyl)propyl cyanide収率 100%

試薬・触媒・溶媒 3

HCID 180Acetone溶媒HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

A solution of 8.68 g (35.7 mmol) of 4-(3-bromopropyl)-2-methoxy-1-methylbenzene in 50 mL of acetone and 50 mL of EtOH was treated with a solution of 2.8 g (42.8 mmol) of KCN in 20 mL of H2O and heated at reflux overnight. The solvent was removed under reduced pressure and the residue taken up in EtOAc and washed with H2O, then saturated NaCl. Drying over MgSO4 and removal of the solvent under reduced pressure left 6.75 g (100% yield) of the product as an oil. The structure was confirmed by NMR and IR spectroscopy.

後処理

  1. temperatureheated
  2. temperatureat reflux overnight
  3. customThe solvent was removed under reduced pressure
  4. washwashed with H2O
  5. dry with materialDrying over MgSO4 and removal of the solvent under reduced pressure

出典と根拠

ORDレコード
ord-e599833520eb40b18de2ec28474f1937
出典データセット
uspto-grants-2003_03
特許番号
US06528535B2

反応ノート

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