Methanesulfonyl chloride → Ethyl 3-[4-(2-methanesulfonyloxyethoxy)phenyl]-2-phenoxypropionate

HRID 1859959ノート

反応式

HRID 1859959 の反応式
[OH:1][CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH:12]([O:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:7][CH:6]=1.[CH3:25][S:26](Cl)(=[O:28])=[O:27]>C(N(CC)CC)C>[CH3:25][S:26]([O:1][CH2:2][CH2:3][O:4][C:5]1[CH:6]=[CH:7][C:8]([CH2:11][CH:12]([O:18][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:9][CH:10]=1)(=[O:28])=[O:27]

参加物

4

反応物 2

HCID 31297Methanesulfonyl chlorideHCID 18625939Ethyl 3-[4-(2-hydroxyethoxy)phenyl]-2-phenoxypropionate

生成物 1

HCID 18625787Ethyl 3-[4-(2-methanesulfonyloxyethoxy)phenyl]-2-phenoxypropionate

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

実験手順

In a similar manner to that described in Reference example 3(g), a reaction was carried out using ethyl 3-[4-(2-hydroxyethoxy)phenyl]-2-phenoxypropionate (3.27 g), which is the product of Reference example 4(e), triethylamine (2.07 ml) and methanesulfonyl chloride (0.84 ml) and the reaction mixture was treated to afford the desired compound (4.20 g) as a syrup.

後処理

  1. additionthe reaction mixture was treated

出典と根拠

ORDレコード
ord-84c6fb28bba44922b1c081fb738b5545
出典データセット
uspto-grants-2003_03
特許番号
US06528525B1

反応ノート

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