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HRID 1860052作成日:2026年10月26日

Sodium Hydroxide → 2-(5-(Trifluoromethyl)pyridin-2-yl)benzoic acid

https://huagongshe.com/reaction/1860052

反応式

関与物質

役割名称HCID仕込み量
反応物Sodium HydroxideHCID 14798—
反応物Methyl 3-trifluoromethylpyridine-6-ylbenzoateHCID 18625897—
生成物2-(5-(Trifluoromethyl)pyridin-2-yl)benzoic acidHCID 2273690972.7%

反応手順

In a similar manner to that described in Example 2, a reaction was carried out using methyl 3-trifluoromethylpyridine-6-ylbenzoate (791 mg) and aqueous sodium hydroxide solution (1N, 5.60 ml) and the reaction mixture was treated to afford the title compound (546 mg) which includes some impurity and was used in example 106 without further purification.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US06528525B1
出典データセットuspto-grants-2003_03
ORD IDord-c54feab767b34f7c8e3d3a9cfdd867f1
出典メモuspto-grants-2003_03