Ethyl 3-[4-(2-t-butoxycarbonylaminoethoxy)phenyl]-2-hydroxypropionate → Ethyl 2-hydroxy-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate

HRID 1860075ノート

反応式

HRID 1860075 の反応式
C(O[C:6]([NH:8][CH2:9][CH2:10][O:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][CH:19]([OH:25])[C:20]([O:22][CH2:23][CH3:24])=[O:21])=[CH:14][CH:13]=1)=[O:7])(C)(C)C.Cl.[N:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[C:33]1[CH:41]=[CH:40][C:36](C(Cl)=O)=[CH:35][CH:34]=1>C(N(CC)CC)C>[OH:25][CH:19]([CH2:18][C:15]1[CH:14]=[CH:13][C:12]([O:11][CH2:10][CH2:9][NH:8][C:6](=[O:7])[C:36]2[CH:35]=[CH:34][C:33]([C:28]3[CH:29]=[CH:30][CH:31]=[CH:32][N:27]=3)=[CH:41][CH:40]=2)=[CH:17][CH:16]=1)[C:20]([O:22][CH2:23][CH3:24])=[O:21]

参加物

4

反応物 2

HCID 18625730Ethyl 3-[4-(2-t-butoxycarbonylaminoethoxy)phenyl]-2-hydroxypropionateHCID 186259104-(2-Pyridinyl)benzoyl Chloride Hydrochloride

生成物 1

HCID 18625968Ethyl 2-hydroxy-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate収率 91%

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

実験手順

In a similar manner to that described in Example 126, a reaction was carried out using ethyl 3-[4-(2-t-butoxycarbonylaminoethoxy)phenyl]-2-hydroxypropionate (168 mg), 4-pyridine-2-ylbenzoylchloride hydrochloride (126 mg) and triethylamine (0.28 ml) and the reaction mixture was treated to afford the title compound (188 mg) as colorless crystals.

後処理

  1. additionthe reaction mixture was treated

出典と根拠

ORDレコード
ord-ddbc3c231a354e7d9245f9d85f3efe5f
出典データセット
uspto-grants-2003_03
特許番号
US06528525B1

反応ノート

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