Ethyl 3-(4-benzyloxyphenyl)-2-aminopropionate → Ethyl 3-(4-benzyloxyphenyl)-2-(pyrrole-1-yl)propionate

HRID 1860103ノート

反応式

HRID 1860103 の反応式
Cl[CH:2](OC)[CH2:3][CH2:4][CH:5](Cl)OC.[CH2:11]([O:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][CH:26]([NH2:32])[C:27]([O:29][CH2:30][CH3:31])=[O:28])=[CH:21][CH:20]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>ClCCl>[CH2:11]([O:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][CH:26]([N:32]2[CH:5]=[CH:4][CH:3]=[CH:2]2)[C:27]([O:29][CH2:30][CH3:31])=[O:28])=[CH:21][CH:20]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

参加物

4

反応物 2

HCID 4681968Ethyl 3-(4-benzyloxyphenyl)-2-aminopropionateHCID 128533161,4-Dichloro-1,4-dimethoxybutane

生成物 1

HCID 18625911Ethyl 3-(4-benzyloxyphenyl)-2-(pyrrole-1-yl)propionate収率 26%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

1,4-dichloro-1,4-dimethoxybutane (3.30 g) was added to a solution of ethyl 3-(4-benzyloxyphenyl)-2-aminopropionate (3.30 g) in dichloromethane (80 ml) and then amberlyst A-21 (20 g) was added to the mixture. The mixture was stirred at ambient temperature for 18 hours and the reaction mixture was filtered. The filtrate was concentrated and the residue was purified via chromatography on a silica gel column using ethyl acetate/hexane=1/5 as the eluant to afford the desired compound (1.00 g) as a syrup.

後処理

  1. additionamberlyst A-21 (20 g) was added to the mixture
  2. filtrationthe reaction mixture was filtered
  3. concentrationThe filtrate was concentrated
  4. customthe residue was purified via chromatography on a silica gel column

出典と根拠

ORDレコード
ord-a84d82773088476f828f7fcd75eee02b
出典データセット
uspto-grants-2003_03
特許番号
US06528525B1

反応ノート

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