Potassium Hydroxide → Flumethasone

反応式

[CH3:1][C@H:2]1[C@:19]([OH:27])([C:20]([CH2:22][O:23]C(C)=O)=[O:21])[C@:18]2([CH3:28])[C@H:4]([C@H:5]3[C@:15]([F:30])([C@@H:16]([OH:29])[CH2:17]2)[C@:14]2([CH3:31])[C:8](=[CH:9][C:10]([CH:12]=[CH:13]2)=[O:11])[C@@H:7]([F:32])[CH2:6]3)[CH2:3]1.[OH-].[K+]>>[CH3:1][C@H:2]1[C@:19]([OH:27])([C:20]([CH2:22][OH:23])=[O:21])[C@:18]2([CH3:28])[C@H:4]([C@H:5]3[C@:15]([F:30])([C@@H:16]([OH:29])[CH2:17]2)[C@:14]2([CH3:31])[C:8](=[CH:9][C:10]([CH:12]=[CH:13]2)=[O:11])[C@@H:7]([F:32])[CH2:6]3)[CH2:3]1

参加物

反応物 2

HCID 14797Potassium Hydroxide

HCID 11155198Flumethasone Acetate

生成物 1

HCID 16490Flumethasone

実験手順

A process according to claim 1, characterized by the fact that the flumethasone 21-acetate is reacted with methanolic potassium hydroxide in the absence of an oxidization agent to yield flumethasone.

出典と根拠

ORDレコード: ord-f41311e2dbb145aca0f11adab5579f21
出典データセット: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06528666B1

反応ノート

読み込み中…