Methyl 2,2,2-trichloroacetimidate → 4-[2-(tert-Butyl-dimethyl-silanyloxy)-ethoxy]-2-trichloromethyl-1H-benzoimidazole
反応式
[C:1]([Si:5]([CH3:19])([CH3:18])[O:6][CH2:7][CH2:8][O:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([NH2:16])[C:11]=1[NH2:17])([CH3:4])([CH3:3])[CH3:2].CO[C:22](=N)[C:23]([Cl:26])([Cl:25])[Cl:24]>>[C:1]([Si:5]([CH3:19])([CH3:18])[O:6][CH2:7][CH2:8][O:9][C:10]1[C:11]2[N:17]=[C:22]([C:23]([Cl:26])([Cl:25])[Cl:24])[NH:16][C:12]=2[CH:13]=[CH:14][CH:15]=1)([CH3:4])([CH3:3])[CH3:2]参加物
3
実験手順
4-[2-(tert-Butyl-dimethyl-silanyloxy)-ethoxy]-2-trichloromethyl-1H-benzoimidazole was prepared by a procedure according to example 108 (iii) starting from 503 mg (1.78 mmol) 3-[2-(tert-Butyl-dimethyl-silanyloxy)-ethoxy]-benzene-1,2-diamine and 0.31 mL (2.49 mmol) 2,2,2-trichloro-acetimidic acid methyl ester. Yield: 680 mg MS (ES+): m/e=409, chloro pattern.
出典と根拠
- ORDレコード
- ord-bba2c92ab44f49fc867634839f0fdc10
- 出典データセット
- uspto-grants-2010_06