2-{1-(Methoxycarbonyl)ethoxy}-3-nitropyridine → 3-Amino-2-{1-(methoxycarbonyl)ethoxy}pyridine

HRID 1862261ノート

反応式

HRID 1862261 の反応式
[CH3:1][O:2][C:3]([CH:5]([O:7][C:8]1[C:13]([N+:14]([O-])=O)=[CH:12][CH:11]=[CH:10][N:9]=1)[CH3:6])=[O:4]>[Pt]=O.C(O)C>[NH2:14][C:13]1[C:8]([O:7][CH:5]([C:3]([O:2][CH3:1])=[O:4])[CH3:6])=[N:9][CH:10]=[CH:11][CH:12]=1

参加物

4

反応物 1

HCID 219335712-{1-(Methoxycarbonyl)ethoxy}-3-nitropyridine

生成物 1

HCID 219335303-Amino-2-{1-(methoxycarbonyl)ethoxy}pyridine収率 78.7%

試薬・触媒・溶媒 2

HCID 82844Platinum oxide (PtO)触媒HCID 702Ethanol溶媒

実験手順

A mixture of 1.7 g of 2-{1-(methoxycarbonyl)ethoxy}-3-nitropyridine, 102 mg of platinum oxide and 7.5 ml of ethanol was stirred for 3.5 hours at room temperature under hydrogen atmosphere. The reaction system was purged with nitrogen, then, the reaction solution was filtrated through Celite, and the filtrate was concentrated. The residue was subjected to silica gel column chromatography to obtain 1.16 g of 3-amino-2-{1-(methoxycarbonyl)ethoxy}pyridine.

後処理

  1. customThe reaction system was purged with nitrogen
  2. filtrationthe reaction solution was filtrated through Celite
  3. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-edfbf264ea944565820c9af1c7946d5e
出典データセット
uspto-grants-2003_03
特許番号
US06537948B1

反応ノート

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