Hydrochloric Acid → 4-(Benzyloxy)pyridin-3-ol

HRID 1862274ノート

反応式

HRID 1862274 の反応式
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][N:12]=[CH:11][C:10]=1[O:15]COC)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.C(=O)(O)[O-].[Na+]>>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][N:12]=[CH:11][C:10]=1[OH:15])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 186191724-Benzyloxy-3-methoxymethoxypyridine

生成物 1

HCID 186192064-(Benzyloxy)pyridin-3-ol収率 95.3%

反応条件

温度
60 °C

実験手順

A mixture of 0.7 g of 4-benzyloxy-3-methoxymethoxypyridine and 1N hydrochloric acid was stirred for 2 hours at 60° C. The mixture was poured into saturated aqueous sodium bicarbonate solution, extracted with ethyl acetate. The organic layer is washed with saturated saline, dried over anhydrous magnesium sulfate, concentrated to obtain 0.547 g of 4-benzyloxy-3-hydroxypyridine.

後処理

  1. extractionextracted with ethyl acetate
  2. washThe organic layer is washed with saturated saline
  3. dry with materialdried over anhydrous magnesium sulfate
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-331f82de50ac43bbaaf12280a2691e1b
出典データセット
uspto-grants-2003_03
特許番号
US06537948B1

反応ノート

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